Two sample MR report

Telomere_length against IDP dMRI ProbtrackX L1 fma

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0736740	0.1144270	0.5266418
Weighted median	23	0.1230616	0.0626600	0.0495351
Inverse variance weighted	23	0.0771492	0.0457748	0.0919098
Simple mode	23	0.0304995	0.1270560	0.8125158
Weighted mode	23	0.0920964	0.0960682	0.3481499

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.28512	21	0.1616140
Inverse variance weighted	29.94931	22	0.1197016

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0092613	0.0064676	0.1668731

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010247	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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