Two sample MR report

Telomere_length against IDP dMRI ProbtrackX L1 cst r

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2274112	0.1003870	0.0341888
Weighted median	23	0.0950820	0.0560075	0.0895708
Inverse variance weighted	23	0.0380648	0.0392327	0.3319313
Simple mode	23	0.0857156	0.0976861	0.3897193
Weighted mode	23	0.0995867	0.0605245	0.1141020

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	14.65307	21	0.8399487
Inverse variance weighted	18.85203	22	0.6544473

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0116268	0.005674	0.0531489

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005998	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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