Two sample MR report

Telomere_length against IDP dMRI ProbtrackX L1 cst l

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0944416	0.1088183	0.3952681
Weighted median	23	0.0938681	0.0570738	0.1000361
Inverse variance weighted	23	0.0545416	0.0417064	0.1909575
Simple mode	23	0.0937493	0.0952077	0.3354864
Weighted mode	23	0.0810543	0.0654943	0.2289190

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.67518	21	0.2615063
Inverse variance weighted	24.86163	22	0.3037376

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.00245	0.0061506	0.6943964

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008119	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8