Two sample MR report

Telomere_length against IDP dMRI ProbtrackX L1 cgh r

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1676854	0.1003834	0.1096691
Weighted median	23	0.1734618	0.0559080	0.0019181
Inverse variance weighted	23	0.1753232	0.0392317	0.0000079
Simple mode	23	0.2151507	0.0956703	0.0348653
Weighted mode	23	0.1951281	0.0698385	0.0105789

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.17285	21	0.7598618
Inverse variance weighted	16.17968	22	0.8068689

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.000469	0.0056739	0.9349041

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010954	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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