Two sample MR report

Telomere_length against IDP dMRI ProbtrackX L1 cgh l

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1018603	0.1125246	0.3756139
Weighted median	23	0.1936852	0.0608658	0.0014618
Inverse variance weighted	23	0.1344459	0.0430664	0.0017973
Simple mode	23	0.2063220	0.1005400	0.0522434
Weighted mode	23	0.1837099	0.0688981	0.0141006

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.38620	21	0.1921044
Inverse variance weighted	26.51056	22	0.2304075

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0020009	0.0063601	0.756164

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011592	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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