Two sample MR report

Telomere_length against IDP dMRI ProbtrackX L1 cgc r

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0392312	0.1661567	0.8156352
Weighted median	23	-0.0027694	0.0632999	0.9651033
Inverse variance weighted	23	0.0930652	0.0636293	0.1435728
Simple mode	23	0.0033938	0.1596687	0.9832338
Weighted mode	23	-0.0142126	0.0760319	0.8534290

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	57.53150	21	3.00e-05
Inverse variance weighted	57.87093	22	4.59e-05

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0033056	0.0093913	0.7283547

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0019239	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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