Two sample MR report

Telomere_length against IDP dMRI ProbtrackX L1 cgc l

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1397239	0.1551501	0.3780277
Weighted median	23	0.0662373	0.0648760	0.3072620
Inverse variance weighted	23	0.1618838	0.0592734	0.0063116
Simple mode	23	0.3584786	0.1593036	0.0347626
Weighted mode	23	0.0357259	0.0841800	0.6753963

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	50.16188	21	0.0003463
Inverse variance weighted	50.21939	22	0.0005477

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0013607	0.0087693	0.87817

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0020374	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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