Two sample MR report

Telomere_length against IDP dMRI ProbtrackX L1 atr r

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1651753	0.1259011	0.2037002
Weighted median	23	0.1441501	0.0567031	0.0110161
Inverse variance weighted	23	0.1706754	0.0480744	0.0003849
Simple mode	23	0.1000413	0.0824157	0.2376713
Weighted mode	23	0.1235764	0.0554056	0.0362393

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	33.03107	21	0.0458737
Inverse variance weighted	33.03462	22	0.0613886

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0003377	0.0071161	0.9625943

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0015741	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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