Two sample MR report

Telomere_length against IDP dMRI ProbtrackX L1 atr l

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0646495	0.1180609	0.5897438
Weighted median	23	0.1214592	0.0573331	0.0341343
Inverse variance weighted	23	0.1740254	0.0461529	0.0001628
Simple mode	23	0.1018763	0.0964165	0.3021472
Weighted mode	23	0.1139849	0.0571241	0.0585305

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.04548	21	0.1129139
Inverse variance weighted	30.44658	22	0.1080079

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0067162	0.006673	0.3256417

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0015186	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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