Two sample MR report

Telomere_length against IDP dMRI ProbtrackX L1 ar r

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2155096	0.1382737	0.1340413
Weighted median	23	0.1034272	0.0587620	0.0783906
Inverse variance weighted	23	0.1541333	0.0530885	0.0036922
Simple mode	23	0.0378216	0.0980341	0.7033499
Weighted mode	23	0.0675924	0.0623145	0.2897997

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	39.84339	21	0.0077697
Inverse variance weighted	40.28459	22	0.0100129

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0037688	0.0078155	0.6346324

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0016882	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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