Two sample MR report

Telomere_length against IDP dMRI ProbtrackX L1 ar l

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0615846	0.1239497	0.6244553
Weighted median	23	0.0422231	0.0584798	0.4702865
Inverse variance weighted	23	0.1361192	0.0478062	0.0044091
Simple mode	23	0.0444048	0.1257976	0.7274583
Weighted mode	23	0.0341128	0.0667902	0.6146170

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	32.01569	21	0.0583364
Inverse variance weighted	32.66634	22	0.0667241

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0045768	0.0070058	0.5206616

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0013546	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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