Two sample MR report

Telomere_length against IDP dMRI ProbtrackX ISOVF unc r

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1571758	0.1017922	0.1375046
Weighted median	23	0.1385016	0.0588587	0.0186167
Inverse variance weighted	23	0.0876375	0.0393735	0.0260278
Simple mode	23	0.1188831	0.1111104	0.2962387
Weighted mode	23	0.1731107	0.0820494	0.0464770

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.59146	21	0.4233707
Inverse variance weighted	22.15778	22	0.4505057

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.00427	0.0057535	0.4662088

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008226	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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