Two sample MR report

Telomere_length against IDP dMRI ProbtrackX ISOVF unc l

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2135488	0.1003898	0.0454186
Weighted median	23	0.0878729	0.0567513	0.1215292
Inverse variance weighted	23	0.0440631	0.0395995	0.2658299
Simple mode	23	0.0751857	0.0916158	0.4206417
Weighted mode	23	0.0967747	0.0615504	0.1301566

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.04837	21	0.5820369
Inverse variance weighted	22.41246	22	0.4355130

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0104072	0.0056741	0.0808431

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007174	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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