Two sample MR report

Telomere_length against IDP dMRI ProbtrackX ISOVF str r

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1177688	0.1391617	0.4069410
Weighted median	23	0.0527599	0.0585435	0.3674775
Inverse variance weighted	23	0.0948434	0.0531762	0.0744938
Simple mode	23	0.0634472	0.1013888	0.5378967
Weighted mode	23	0.0437102	0.0597795	0.4723801

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	40.35427	21	0.0067325
Inverse variance weighted	40.41582	22	0.0096634

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0014077	0.0078655	0.8596747

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0014017	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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