Two sample MR report

Telomere_length against IDP dMRI ProbtrackX ISOVF str l

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1820839	0.1113946	0.1170387
Weighted median	23	0.1281748	0.0538419	0.0172855
Inverse variance weighted	23	0.1131440	0.0429887	0.0084897
Simple mode	23	0.1285649	0.0846527	0.1430710
Weighted mode	23	0.1285649	0.0592336	0.0410401

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.85708	21	0.2119509
Inverse variance weighted	26.41370	22	0.2343443

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0042333	0.0062962	0.5086903

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010523	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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