Two sample MR report

Telomere_length against IDP dMRI ProbtrackX ISOVF slf r

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0866727	0.1481351	0.5647204
Weighted median	23	0.0949291	0.0585883	0.1051736
Inverse variance weighted	23	0.1776333	0.0571575	0.0018849
Simple mode	23	0.2581800	0.1069686	0.0245660
Weighted mode	23	0.1031804	0.0586162	0.0922598

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	45.72654	21	0.0013892
Inverse variance weighted	46.69553	22	0.0016078

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0055853	0.0083727	0.5119786

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0020358	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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