Two sample MR report

Telomere_length against IDP dMRI ProbtrackX ISOVF slf l

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0514365	0.1444416	0.7253137
Weighted median	23	0.1121157	0.0588056	0.0565793
Inverse variance weighted	23	0.1718279	0.0562176	0.0022395
Simple mode	23	0.2847832	0.1027990	0.0111626
Weighted mode	23	0.0983904	0.0612165	0.1222578

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	43.47467	21	0.0027329
Inverse variance weighted	45.17214	22	0.0025235

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0073925	0.0081639	0.3754682

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0019495	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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