Two sample MR report

Telomere_length against IDP dMRI ProbtrackX ISOVF ptr r

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0249878	0.1025805	0.8099110
Weighted median	23	-0.0787376	0.0574932	0.1708394
Inverse variance weighted	23	-0.0592001	0.0392902	0.1318774
Simple mode	23	-0.0514114	0.0868904	0.5600955
Weighted mode	23	-0.0552032	0.0628273	0.3890876

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.92637	21	0.4037637
Inverse variance weighted	22.06344	22	0.4561073

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0021008	0.0057979	0.7207241

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007376	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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