Two sample MR report

Telomere_length against IDP dMRI ProbtrackX ISOVF ptr l

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0338752	0.1003896	0.7391369
Weighted median	23	0.0685963	0.0581394	0.2380557
Inverse variance weighted	23	-0.0032185	0.0392335	0.9346185
Simple mode	23	0.0947084	0.1011288	0.3591768
Weighted mode	23	0.1016151	0.1000431	0.3208068

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.25362	21	0.5688745
Inverse variance weighted	19.36368	22	0.6227763

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0018825	0.0056742	0.7433576

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000587	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8