Two sample MR report

Telomere_length against IDP dMRI ProbtrackX ISOVF ml r

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0447282	0.1018902	0.6651563
Weighted median	23	0.0399937	0.0584337	0.4937044
Inverse variance weighted	23	0.0234907	0.0392336	0.5493470
Simple mode	23	-0.0222332	0.0979124	0.8224645
Weighted mode	23	0.0396205	0.0782562	0.6176876

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.63244	21	0.4209491
Inverse variance weighted	21.68526	22	0.4788035

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0013041	0.005759	0.8230453

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000668	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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