Two sample MR report

Telomere_length against IDP dMRI ProbtrackX ISOVF ml l

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0625919	0.1218949	0.6129685
Weighted median	23	0.0211963	0.0578286	0.7139654
Inverse variance weighted	23	0.0257783	0.0472248	0.5851594
Simple mode	23	0.0469400	0.0903515	0.6085818
Weighted mode	23	0.0148928	0.0629512	0.8151735

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	30.96055	21	0.0743171
Inverse variance weighted	31.87510	22	0.0795505

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0054263	0.0068896	0.439726

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009789	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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