Two sample MR report

Telomere_length against IDP dMRI ProbtrackX ISOVF mcp

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1424506	0.1120647	0.2175770
Weighted median	23	0.1113995	0.0607940	0.0668903
Inverse variance weighted	23	0.0368521	0.0438443	0.4006156
Simple mode	23	0.1107149	0.1130949	0.3382454
Weighted mode	23	0.1298671	0.0764925	0.1036524

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.16924	21	0.2000691
Inverse variance weighted	27.47521	22	0.1937310

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0064842	0.006334	0.3176181

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008593	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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