Two sample MR report

Telomere_length against IDP dMRI ProbtrackX ISOVF ilf r

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0222519	0.1214403	0.8563724
Weighted median	23	-0.0167220	0.0565589	0.7674923
Inverse variance weighted	23	0.0434679	0.0467492	0.3524684
Simple mode	23	-0.0303196	0.0932584	0.7481668
Weighted mode	23	-0.0096307	0.0607893	0.8755652

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	30.73016	21	0.0782675
Inverse variance weighted	31.23598	22	0.0913869

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0040355	0.0068639	0.5628507

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009836	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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