Two sample MR report

Telomere_length against IDP dMRI ProbtrackX ISOVF ilf l

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0850870	0.1239927	0.5000777
Weighted median	23	0.0229840	0.0595525	0.6995370
Inverse variance weighted	23	0.0673169	0.0493129	0.1722226
Simple mode	23	0.0312419	0.0988797	0.7550119
Weighted mode	23	0.0114525	0.0667215	0.8652849

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	32.03619	21	0.0580581
Inverse variance weighted	34.75641	22	0.0410756

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0093582	0.0070081	0.1960612

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011423	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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