Two sample MR report

Telomere_length against IDP dMRI ProbtrackX ISOVF ifo r

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1441606	0.1434191	0.3262572
Weighted median	23	-0.0332480	0.0590714	0.5735409
Inverse variance weighted	23	0.0078814	0.0564642	0.8889899
Simple mode	23	-0.0918851	0.0995460	0.3659992
Weighted mode	23	-0.0621818	0.0638652	0.3408194

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	42.86169	21	0.0032737
Inverse variance weighted	45.56903	22	0.0022459

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0093361	0.0081062	0.2623802

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0013818	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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