Two sample MR report

Telomere_length against IDP dMRI ProbtrackX ISOVF ifo l

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0568013	0.1167273	0.6315713
Weighted median	23	-0.0020165	0.0572393	0.9718969
Inverse variance weighted	23	0.0251892	0.0451833	0.5771933
Simple mode	23	-0.0672829	0.0932312	0.4780931
Weighted mode	23	-0.0191497	0.0686794	0.7829816

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.39133	21	0.1293977
Inverse variance weighted	29.17861	22	0.1398317

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0050346	0.0065975	0.4538923

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008966	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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