Two sample MR report

Telomere_length against IDP dMRI ProbtrackX ISOVF fmi

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0759408	0.1150573	0.5164118
Weighted median	23	-0.0445069	0.0621432	0.4738686
Inverse variance weighted	23	0.0011742	0.0444833	0.9789417
Simple mode	23	-0.2193777	0.1151456	0.0699052
Weighted mode	23	-0.0762073	0.0738489	0.3133139

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.58502	21	0.1523178
Inverse variance weighted	28.28146	22	0.1665400

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0047352	0.0065032	0.4745696

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000857	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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