Two sample MR report

Telomere_length against IDP dMRI ProbtrackX ISOVF fma

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1909149	0.1517814	0.2222616
Weighted median	23	-0.0591913	0.0613402	0.3345616
Inverse variance weighted	23	0.0290141	0.0612780	0.6358689
Simple mode	23	-0.0562759	0.1132014	0.6240285
Weighted mode	23	-0.1404809	0.0784455	0.0870952

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	48.00646	21	0.0006863
Inverse variance weighted	53.67129	22	0.0001830

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0135048	0.008579	0.1303927

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0016425	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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