Two sample MR report

Telomere_length against IDP dMRI ProbtrackX ISOVF cst r

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1761471	0.1003902	0.0939049
Weighted median	23	0.0503832	0.0561941	0.3699363
Inverse variance weighted	23	0.0352484	0.0392336	0.3689604
Simple mode	23	0.0950367	0.0873258	0.2882417
Weighted mode	23	0.0628257	0.0642172	0.3385473

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.42504	21	0.7453144
Inverse variance weighted	18.74998	22	0.6607122

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0086518	0.0056741	0.1422348

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005926	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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