Two sample MR report

Telomere_length against IDP dMRI ProbtrackX ISOVF cst l

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0362161	0.1003895	0.7218856
Weighted median	23	0.0734098	0.0580368	0.2059133
Inverse variance weighted	23	0.1082254	0.0392334	0.0058067
Simple mode	23	0.0985812	0.0927971	0.2996086
Weighted mode	23	0.0826052	0.0670209	0.2307617

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	15.08781	21	0.8185203
Inverse variance weighted	15.69507	22	0.8307257

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0044217	0.0056741	0.4445121

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007062	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8