Two sample MR report

Telomere_length against IDP dMRI ProbtrackX ISOVF cgh l

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0871330	0.1003892	0.3952314
Weighted median	23	0.0772258	0.0576302	0.1802378
Inverse variance weighted	23	0.0460472	0.0392336	0.2405282
Simple mode	23	0.1015765	0.0868115	0.2544883
Weighted mode	23	0.0928190	0.0625247	0.1518594

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	15.54617	21	0.7945837
Inverse variance weighted	15.74386	22	0.8283915

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0025229	0.0056741	0.6611384

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005188	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8