Two sample MR report

Telomere_length against IDP dMRI ProbtrackX ISOVF cgc r

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0713741	0.1296123	0.5876686
Weighted median	23	-0.0399778	0.0644422	0.5350159
Inverse variance weighted	23	0.0276337	0.0502943	0.5827041
Simple mode	23	-0.1486135	0.1362883	0.2873215
Weighted mode	23	-0.1055770	0.0840969	0.2224972

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	35.00598	21	0.0281925
Inverse variance weighted	36.15400	22	0.0292320

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0060795	0.0073259	0.4159441

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011105	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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