Two sample MR report

Telomere_length against IDP dMRI ProbtrackX ISOVF cgc l

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0041152	0.1391169	0.9766808
Weighted median	23	0.1221979	0.0652123	0.0609516
Inverse variance weighted	23	0.1077003	0.0540737	0.0464005
Simple mode	23	0.2342681	0.1241247	0.0723757
Weighted mode	23	0.2405617	0.1172817	0.0523481

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	40.32870	21	0.0067811
Inverse variance weighted	41.79296	22	0.0066217

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.006866	0.0078631	0.3924324

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0014947	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8