Two sample MR report

Telomere_length against IDP dMRI ProbtrackX ISOVF atr r

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0327232	0.1198415	0.7874792
Weighted median	23	-0.0032078	0.0589783	0.9566251
Inverse variance weighted	23	0.0281846	0.0457602	0.5379479
Simple mode	23	-0.0612191	0.1019392	0.5542800
Weighted mode	23	-0.0156324	0.0632326	0.8070297

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.92602	21	0.0934848
Inverse variance weighted	29.92843	22	0.1202144

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0002787	0.0067736	0.96757

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009225	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8