Two sample MR report

Telomere_length against IDP dMRI ProbtrackX ISOVF atr l

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0665826	0.1233040	0.5948861
Weighted median	23	0.0199257	0.0560644	0.7222850
Inverse variance weighted	23	0.0126119	0.0476233	0.7911435
Simple mode	23	-0.0101094	0.0929548	0.9143817
Weighted mode	23	-0.0032203	0.0651624	0.9610306

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	31.68091	21	0.0630486
Inverse variance weighted	32.41541	22	0.0705844

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0048629	0.0069693	0.4929793

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009853	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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