Two sample MR report

Telomere_length against IDP dMRI ProbtrackX ISOVF ar r

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0065178	0.1374980	0.9626399
Weighted median	23	0.0086557	0.0599622	0.8852219
Inverse variance weighted	23	0.0401723	0.0526708	0.4456394
Simple mode	23	-0.0585303	0.1628461	0.7227071
Weighted mode	23	-0.0792077	0.0816730	0.3426809

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	39.39576	21	0.0087997
Inverse variance weighted	39.65107	22	0.0118719

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.002867	0.0077716	0.7158888

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012333	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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