Two sample MR report

Telomere_length against IDP dMRI ProbtrackX ISOVF ar l

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0369295	0.1003889	0.7166559
Weighted median	23	-0.0136026	0.0561226	0.8084914
Inverse variance weighted	23	0.0508248	0.0392336	0.1951682
Simple mode	23	0.0212666	0.1015293	0.8360146
Weighted mode	23	-0.0218877	0.0633701	0.7330789

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.15870	21	0.5112300
Inverse variance weighted	21.06057	22	0.5169973

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0053885	0.0056741	0.3530813

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000689	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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