Two sample MR report

Telomere_length against IDP dMRI ProbtrackX ICVF unc r

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1337735	0.1582709	0.4075163
Weighted median	23	-0.1845308	0.0618195	0.0028359
Inverse variance weighted	23	-0.2265608	0.0610112	0.0002045
Simple mode	23	-0.1214665	0.1000380	0.2375431
Weighted mode	23	-0.1299270	0.0690497	0.0731822

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	52.19882	21	0.0001789
Inverse variance weighted	53.20713	22	0.0002125

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0056976	0.0089457	0.5310685

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0026215	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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