Two sample MR report

Telomere_length against IDP dMRI ProbtrackX ICVF unc l

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1283061	0.1520726	0.4083367
Weighted median	23	-0.1871799	0.0565347	0.0009300
Inverse variance weighted	23	-0.2240586	0.0587073	0.0001353
Simple mode	23	-0.1758605	0.0907544	0.0655933
Weighted mode	23	-0.1438792	0.0646724	0.0366696

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	48.18972	21	0.0006479
Inverse variance weighted	49.26349	22	0.0007368

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0058797	0.0085954	0.5014236

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.00248	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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