Two sample MR report

Telomere_length against IDP dMRI ProbtrackX ICVF str r

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1987701	0.1504638	0.2006995
Weighted median	23	-0.1757472	0.0582302	0.0025433
Inverse variance weighted	23	-0.2119908	0.0574628	0.0002250
Simple mode	23	-0.1229016	0.0888673	0.1805480
Weighted mode	23	-0.1465162	0.0622379	0.0279080

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	47.17675	21	0.0008890
Inverse variance weighted	47.19722	22	0.0013832

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0008118	0.0085045	0.9248563

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0023141	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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