Two sample MR report

Telomere_length against IDP dMRI ProbtrackX ICVF str l

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1817792	0.1322211	0.1836826
Weighted median	23	-0.1943517	0.0591603	0.0010192
Inverse variance weighted	23	-0.2006053	0.0505139	0.0000715
Simple mode	23	-0.1797871	0.0911150	0.0611674
Weighted mode	23	-0.1646738	0.0632319	0.0161912

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	36.43043	21	0.0195513
Inverse variance weighted	36.47194	22	0.0270103

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.001156	0.0074734	0.8785464

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0018969	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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