Two sample MR report

Telomere_length against IDP dMRI ProbtrackX ICVF slf r

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2123183	0.1566879	0.1898031
Weighted median	23	-0.1520949	0.0579184	0.0086389
Inverse variance weighted	23	-0.1865964	0.0598717	0.0018295
Simple mode	23	-0.1061328	0.0891937	0.2467635
Weighted mode	23	-0.1258598	0.0645937	0.0642251

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	51.15974	21	0.000251
Inverse variance weighted	51.23723	22	0.000398

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0015795	0.0088563	0.8601627

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0022371	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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