Two sample MR report

Telomere_length against IDP dMRI ProbtrackX ICVF slf l

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2535371	0.1622091	0.1329914
Weighted median	23	-0.1593608	0.0593158	0.0072172
Inverse variance weighted	23	-0.2066586	0.0620797	0.0008718
Simple mode	23	-0.1604421	0.0902254	0.0891904
Weighted mode	23	-0.1604421	0.0659415	0.0235539

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	54.82907	21	0.0000749
Inverse variance weighted	55.08645	22	0.0001155

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0028786	0.0091684	0.7566419

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.002509	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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