Two sample MR report

Telomere_length against IDP dMRI ProbtrackX ICVF ptr r

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.3960746	0.1668773	0.0272425
Weighted median	23	-0.2665825	0.0582223	0.0000047
Inverse variance weighted	23	-0.3008914	0.0642974	0.0000029
Simple mode	23	-0.2264302	0.0955463	0.0269862
Weighted mode	23	-0.2553129	0.0594240	0.0002925

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	58.03629	21	2.52e-05
Inverse variance weighted	59.09746	22	3.04e-05

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0058448	0.0094324	0.5421485

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0035715	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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