Two sample MR report

Telomere_length against IDP dMRI ProbtrackX ICVF ptr l

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.4613173	0.1644441	0.0106025
Weighted median	23	-0.2549012	0.0572117	0.0000084
Inverse variance weighted	23	-0.2821719	0.0648488	0.0000135
Simple mode	23	-0.2470617	0.1040628	0.0267382
Weighted mode	23	-0.2683003	0.0624885	0.0002945

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	56.35642	21	4.47e-05
Inverse variance weighted	60.11546	22	2.15e-05

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0110007	0.0092949	0.2498267

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0033879	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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