Two sample MR report

Telomere_length against IDP dMRI ProbtrackX ICVF ml r

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1812012	0.1193454	0.1438527
Weighted median	23	-0.1454234	0.0584479	0.0128432
Inverse variance weighted	23	-0.1239083	0.0458637	0.0068993
Simple mode	23	-0.2330987	0.1011961	0.0310820
Weighted mode	23	-0.1540065	0.0668785	0.0311253

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.68073	21	0.0985939
Inverse variance weighted	30.06517	22	0.1168890

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0035181	0.0067456	0.6074496

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012132	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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