Two sample MR report

Telomere_length against IDP dMRI ProbtrackX ICVF ml l

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2267076	0.1248642	0.0837339
Weighted median	23	-0.1776758	0.0620767	0.0042071
Inverse variance weighted	23	-0.1079462	0.0488740	0.0271980
Simple mode	23	-0.1903034	0.1005375	0.0716070
Weighted mode	23	-0.1771564	0.0704132	0.0196689

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	32.48964	21	0.0521916
Inverse variance weighted	34.14153	22	0.0475202

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0072926	0.0070575	0.3132155

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.001264	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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