Two sample MR report

Telomere_length against IDP dMRI ProbtrackX ICVF mcp

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1844971	0.1207417	0.1414279
Weighted median	23	-0.1077797	0.0578614	0.0625016
Inverse variance weighted	23	-0.1014298	0.0467116	0.0299004
Simple mode	23	-0.0099124	0.1031193	0.9242912
Weighted mode	23	-0.0723671	0.0706520	0.3168365

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	30.37858	21	0.0846403
Inverse variance weighted	31.18670	22	0.0923580

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0051007	0.0068245	0.4630998

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011475	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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