Two sample MR report

Telomere_length against IDP dMRI ProbtrackX ICVF ilf r

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.3145214	0.1642089	0.0691625
Weighted median	23	-0.2020834	0.0589033	0.0006019
Inverse variance weighted	23	-0.2846889	0.0627562	0.0000057
Simple mode	23	-0.1875733	0.0919565	0.0535563
Weighted mode	23	-0.2050502	0.0641576	0.0041708

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	56.19236	21	4.73e-05
Inverse variance weighted	56.29660	22	7.75e-05

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0018319	0.0092815	0.8454354

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0033	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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