Two sample MR report

Telomere_length against IDP dMRI ProbtrackX ICVF ilf l

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2979185	0.1724649	0.0987736
Weighted median	23	-0.2151544	0.0594007	0.0002922
Inverse variance weighted	23	-0.2869477	0.0658576	0.0000132
Simple mode	23	-0.2124514	0.0980251	0.0413082
Weighted mode	23	-0.2212300	0.0686590	0.0039218

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	61.9851	21	6.40e-06
Inverse variance weighted	61.9992	22	1.13e-05

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0006737	0.0097481	0.9455578

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0034981	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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